When undifferentiated, invasive neoplastic cell lines are treated with an optimal time / concentration combination of curcumin (under conditions producing dramatic cell death), a small proportion of surviving cells can undergo a process of redifferentiation. These clones of redifferentiated cells, together with the original tumor cells, could represent interesting biological tools for both academic research (onco-immunology, genetics / epigenetics) and industry research (for example design of cancer vaccines).