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Methods and pharmaceutical compositions for inducing immune tolerance

The present invention relates to methods and pharmaceutical compositions of inducing immune tolerance by mucosal vaccination with Fc-coupled antigens. […]

Antigenic peptides deriving from pcsk2 and uses thereof for the

Despite the notion that human CD8+ T cells are the final mediators of autoimmune β-cell destruction in type 1 diabetes (T1D), none of their target […]

Antigenic peptides deriving from urocortin 3 and uses thereof for the

Despite the notion that human CD8+ T cells are the final mediators of autoimmune β- cell destruction in type 1 diabetes (T1D), none of their target […]

Antigenic peptides deriving from secretogranin v and uses thereof for

Despite the notion that human CD8+ T cells are the final mediators of autoimmune β- cell destruction in type 1 diabetes (T1D), none of their target […]

Use of tnf-alpha blocking agent for preventing, suppressing and/or

Type 1 diabetes (T1D) is an autoimmune disease caused by the destruction of pancreatic β-cells producing insulin. Both T1D patients and animal models […]

Use of an agent capable of inhibiting the activation of mait cells for

Obesity is associated with low-grade inflammation in adipose tissue (AT) and dysfunctional adipocytes producing inflammatory molecules. A recent study […]

Use of new biomarker for selecting and determining response to

Exercise improves metabolic health and prevents the complications of obesity and type 2 diabetes. The inventors hypothesized that skeletal muscle […]

Use of shp2 inhibitors for the treatment of insulin resistance

Despite reaching an epidemic status worldwide, metabolic disorders, notably diabetes, still miss efficient and specific therapeutic strategies because […]

Methods and pharmaceutical compositions for the treatment of chronic

The present invention relates to methods and pharmaceutical compositions for the treatment of chronic kidney disease. The inventors used the CMap […]

Gaba administration induces alpha cell-mediated beta-like cell

GABA is an inducer of α-to-β-like cell conversion in vivo. This conversion induces α cell replacement mechanisms through the mobilization of […]