Methods and pharmaceutical compositions for inducing immune tolerance by mucosal vaccination with fc-coupled antigens

The present invention relates to methods and pharmaceutical compositions of inducing immune tolerance by mucosal vaccination with Fc-coupled antigens. In particular, the present invention relates to a method for inducing tolerance to one antigen of interest in a subject in need thereof, comprising the mucosal administration to the subject of a therapeutically effective amount of a recombinant chimeric construct comprising a FcRn targeting moiety and an antigen-containing moiety.

Inventors:
Slobodan CULINANimesh GUPTARoberto MALLONESébastien LACROIX-DESMAZES

Reference:

BIO15274-T1

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Aymeric Empereur
Aymeric Empereur
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Patent filling date: 2015-07-17

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