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Methods for predicting and treating cardiac dysfunction

Ageing myocardium undergoes structural and functional changes characterized by progressive cardiomyocyte hypertrophy, interstitial fibrosis and […]

Methods and topical pharmaceutical compositions for the treatment of

Microvascular dysfunction remains a major contributor to the development of skin complications. The inventors assessed the impact of the local […]

Methods for diagnosis and monitoring of toxic epidermal necrolysis

In the present invention, inventors investigate the representation of T cell subsets in Toxic epidermal necrolysis (TEN) a life-threatening cutaneous […]

Use of coumarin derivatives for the preparation of drugs for treating

Kallikrein proteolytic cascade plays a crucial role in various skin diseases. A series of coumarinic derivatives were identified with IC50 in the […]

Method for treating t- helper type 2 mediated disease

The present invention relates to the treatment of T- helper type 2 (Th2)-mediated disease. Here, the inventors set out to investigate at the genome […]

Use of antagonists of th17 cytokines for the treatment of bronchial

Bronchial remodelling is a prominent feature of severe asthma and a potential therapeutic target. Some data indicate that Th17 cytokines in particular […]

Use of jak inhibitors for the treatment of painful conditions

An increasing body of evidence suggests that Nav1.7 encoded by SCN9A gene may play a key role in various pain states, including acute, inflammatory […]

Methods and compositions for treating cell senescence accumulation

The inventors have surprisingly demonstrated that GD3 positive senescent cells inhibit NK cell in vitro and in vivo while GD3 negative senescent cells […]

Use of shp2 inhibitors for the treatment of insulin resistance

Despite reaching an epidemic status worldwide, metabolic disorders, notably diabetes, still miss efficient and specific therapeutic strategies because […]

Methods and pharmaceutical compositions for the treatment of chronic

The present invention relates to methods and pharmaceutical compositions for the treatment of chronic kidney disease. The inventors used the CMap […]