Use of coumarin derivatives for the preparation of drugs for treating skin diseases

Kallikrein proteolytic cascade plays a crucial role in various skin diseases. A series of coumarinic derivatives were identified with IC50 in the nanomolar range against kallikreins. Identified coumarinic derivatives are devoided of any cellular toxicity and demonstrated potent in vivo proteolysis inhibition

Keywords: Netherton syndrome
Publications:
Tan X. et al. J Med Chem. 2015 Jan 22;58(2):598-612

Reference:

BIO18503-T1

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