Tp53inp1-deficient mouse

This mouse is deficient for TP53INP1 (both isoforms TP53INP1alpha and TP53INP1beta). TP53INP1 is a key stress factor endowed with a tumor suppressor activity as its transcriptional inducer p53. It is involved in the regulation of p53 activity, in the process of autophagy, and in the control of cell redox state. In human cancers, TP53INP1 is either down-regulated (pancreas, stomach) or overexpressed (thyroid, prostate). TP53INP1-deficient mice are highly susceptible to induced tumorigenesis, in association with increased level of Reactive Oxygen Species (ROS) and defects in antioxidant defences. Hence TP53INP1-deficient mice are a new model of chronic oxidative stressed mice prone to develop tumors, like p53-deficient mice.

Interest / Relevance: Model of chronically stressed mouse (oxidative stress)
Keywords: Tumor suppression , Oxidative stress
- Gommeaux J Cano C Garcia S et al. Colitis and colitis-associated cancer are exacerbated in mice deficient for Tumor Protein 53-Induced Nuclear Protein 1. Mol Cell Biol 2007; 27: 2215-28. - Cano C Gommeaux J Pietri S et al. Tumor Protein 53-Induced Nuclear Protein 1 is a major mediator of p53 antioxidant function. Cancer Research 2009; 69: 219-26. - N'guessan P Pouyet L Gosset G et al. Absence of tumor suppressor Tumor Protein 53-Induced Nuclear Protein 1 sensitizes mouse thymocytes and embryonic fibroblasts to redox-driven apoptosis. Antioxid Redox Signal 2011; 15: 1639-1653.



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Species: Mouse
Genotype: Trp53inp1 -/-
Genetic Background: C57BL/6 and 129/Sv
Applications: Cancer prone
chronic oxidative stress
Rare disease: No
Last update: 13/01/2022

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