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Tailor made high-fat diet fed diabetic mice

We can provide mice a nutritional model of mice which become either type 2 diabetic without obesity, or obese and diabetic or mainly obese.

Interest / Relevance: The interest is related to the targeted disease: diabetes or obesity or metabolic syndrome. it is noteworthy that the diabetic animal can be obtained within a month.these mice are very well adapted for the study of GLP-1 based and antiinflammatory therapies

Keywords: incretins , high fat diet , diabetes , obesity , nutritionnal

Publications:

1. Burcelin R Crivelli V Dacosta A Roy-Tirelli A Thorens B: Heterogeneous metabolic adaptation of C57BL/6J mice to high-fat diet. Am J Physiol Endocrinol Metab 282:E834-842 20022.Sulpice T Prunet-Marcassus B Molveaux C Cani PD Vitte PA Graber P Dreano M Burcelin R: An adiponectin-like molecule with antidiabetic properties. Endocrinology 150:4493-4501 20093.Riant E Waget A Cogo H Arnal JF Burcelin R Gourdy P: Estrogens protect against high-fat diet-induced insulin resistance and glucose intolerance in mice. Endocrinology 150:2109-2117 2009

Reference:

RT00404

Type of research tool: Laboratory Animals

Therapy area(1): Immunology

Therapy area(2): Metabolic Disorders

Therapy area(3): Nutritional disorder

Uses(1): Academic Research

Uses(2): Proof of concept in vivo

Uses(3): Industry Research (screening, tox.studies, bioreactor, ...)

Uses(4): Diagnostic

Uses(5): Therapeutic

Antibody applications: In vivo studies

Inserm Transfert
Research Tools

Species: Mouse

Genotype: Wild type

Strain: C57bl6

Genetic Background: C57bl6

Applications: Type 2 diabetes, obesity, metabolic syndrome

Rare disease: No

Last update: 12/06/2024

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