Rat anti-mouse cd90 (mouse thy-1, monomorphic) (several clones)

A collection of rat monoclonal antibodies recognizing monomorphic determinants of the mouse Thy-1 moecule (CD90) located in two spatially distinct epitope regions:Epitope B : H154-161 (IgG2c) ; H154-190, H154-11 (IgM) ; H140-61, H140-150 (IgG2b)Epitope C : H154-236, H154-57, H155-124, H154-262 (IgG2c), H154-177, H154-200 (IgG2b)

Interest / Relevance: The rat monoclonal antibodies reactive with Thy-1 epitope C are capabable of activating T hybridoma cells to produce IL-2 (upon cross-linking at the cell membrane). They also stimulate IL2 receptor expression by mouse thymocytes.Trigger mouse thymocyte apoptosis through a bcl2-resistant mechanis.Block adhesion of mouse thymocytes to thymic epithelial cells

Keywords: null

Scientist's name: Michel PIERRES
P. NAQUET, Hai-Tao HE (CIML)

Publications:

Pont S et al. Analysis of the Thy-1 pathway of Tcell hybridoma activation using 17 rat monoclonal antibodies reactive with distinct Thy-1 epitopes (1985) Eur. J. Immunol. 15 : 1222-1228He H.T. et al (1991) Thy-1 supports adhesion of mouse thymocytes to thymic epithelial cells through a ca2+-independent mechanism. J. Exp. Med. 173 : 515-518A.-O. Hueber et al. (1994) J. Exp. Med 179 : 785-96

Reference:

RT00354

Type of research tool: Antibodies

Therapy area(1): Immunology

Uses(1): Academic Research

Uses(2): Industry Research (screening, tox.studies, bioreactor, ...)

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Clones available: Epitope B : H154-161 (IgG2c)
H154-190, H154-11 (IgM)
H140-61, H140-150 (IgG2b). Epitope C : H154-236, H154-57, H155-124, H154-262 (IgG2c), H154-177, H154-200 (IgG2b)

IgG2c, IgG2b

Isotype: IgG2c, IgG2b

null

Source: null

null

Specificity: null

Immunogen Seq ID: Mouse T cells

Cellular Distribution: null

Know Cross Reactivity: null

Depositor: M. PIERRES

FBS: 10%

Rare disease: No

Last update: 18/06/2024

Rat anti-mouse cd90 (mouse thy-1, monomorphic) (several clones)

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