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Hahlh (hahr) cell line

HAHLH were generated by transfection of cervical cancer HeLa cells with the XRE(TnGCGTG)3-TATA-Luciferase-SV40-Hygromycin plasmid. rnThe plasmid XRE(TnGCGTG)3-TATA -Luc-SVHygro contains a luciferase gene driven by three AhR responsive elements and a hygromycin gene under the control of SV40 promoter. rn

Interest / Relevance: These cells enable to measure the hAhR activity (full and partial agonism, antagonism) of pharmaceuticals, environmental compounds (HAPs, PCBs, dioxins). rnThese cells enable to measure the hAhR activity of environmental (water, sediments), human (blood, urine adipose tissue) or food (water, vegetables, meat) samples.rnrnDioxin EC50 5 nMrn

Keywords: hAhR, luciferase, pharmaceutical and environmental hAhR ligands

Scientist's name: Patrick BALAGUER
Patrick Balaguer

Publications:

Gruszczyk J Grandvuillemin L Lai-Kee-Him J Paloni M Christos G Savva CG Germain P Grimaldi M Boulahtouf A Kwong HK Bous J Ancelin A Bechara C Barducci A Balaguer P Bourguet W. Cryo-EM structure of the agonist-bound Hsp90-XAP2-AHR cytosolic complex. Nat Commun 2022 Nov 1613(1):7010.

Reference:

RT00618

Type of research tool: Cell Lines

Uses(1): Industry Research (screening, tox.studies, bioreactor, ...)

Inserm Transfert
Research Tools

Organism: null

Tissue: null

Morphology: null

Passage Number: null

Subculture Routine: null

Culture Medium: null

Growth Properties: null

Karyotype: null

Rare disease: No

Last update: 12/06/2024

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