147

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310

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Prkcdg510s/g510s mice – preclinical model of lupus

We introduced the Prkcd G510S mutation that we previously associated to a Mendelian cause of SLE in the mouse genome, by means of CRISPR-Cas9 gene […]

Tssp-deficient mice, a model to identify new essential diabetogenic

TSSP is a novel protease suspected to edit the peptide repertoire presented by MHC class II molecules in the thymus. Prss16, the gene coding for TSSP […]

Hu-ucp3 transgenic mice (moderate overexpr.) resistant to high

Uncoupling protein (UCP) 3 is a mitochondrial inner membrane protein expressed predominantly in glycolytic skeletal muscles.Transgenic mice were […]

Transgenic mouse model for myotonic dystrophy: dmsxl carrying >1000

This transgenic mice model ("DMSXL") contains large human genomic DNA sequence carrying the DMPK gene with very large repeat (>1200 CTG). […]

Tp53inp1-deficient mouse

This mouse is deficient for TP53INP1 (both isoforms TP53INP1alpha and TP53INP1beta). TP53INP1 is a key stress factor endowed with a tumor suppressor […]

Transgenic mouse model for myotonic dystrophy: dm300 carrying 300 ctg

Transgenic mouse model carrying the myotonic dystrophy type 1 (DM1) locus (45kb of human sequences) with the DMPK gene and about 300 unstable CTG […]

Tailor made high-fat diet fed diabetic mice

We can provide mice a nutritional model of mice which become either type 2 diabetic without obesity, or obese and diabetic or mainly obese. […]

Scavenger receptor bi knockout mouse

The class B, type I scavenger receptor (Srb1 or Scarb1) is a cell surface HDL receptor. It plays a key role in determining the levels of plasma […]

Gfp-tagged mucin-reporter mouse model

To follow a gel-forming mucin production, we tagged with a GFP variant a mouse mucin gene. This reporter mouse allow also to follow goblet cell number […]

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