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Germ free humanized diabetic/obese mice

These germ free mice are colonized with human microflora and fed a high fat diet which allows the study of the impact of pre and probiotics on the control of metabolic diseases.

Interest / Relevance: This animal model is unique since it allows the validation of any nutritional strategy that aims at controling the relationship between intestinal microbiota and metabolic disease. Immunomodulatory strategies are also suitable using this model.

Keywords: Germ free , Diabetes , Obesity , High fat diet , Metabolic syndrome

Publications:

1. Cani P Amar J Iglesias M Poggi M Knauf C Bastelica D Neyrinck A Fava F Tuohy K Chabo C Waget A Delmée E Cousin B Sulpice T Chamontin B Ferrières J Tanti J Gibson G Casteilla L Delzenne N Alessi M Burcelin R: Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 56:1761-1772 20072. Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice.Cani PD Bibiloni R Knauf C Waget A Neyrinck AM Delzenne NM Burcelin R.Diabetes. 2008;57(6):1470-81.

Reference:

RT00405

Type of research tool: Laboratory Animals

Therapy area(1): Immunology

Therapy area(2): Metabolic Disorders

Therapy area(3): Nutritional disorder

Uses(1): Academic Research

Uses(2): Proof of concept in vivo

Uses(3): Industry Research (screening, tox.studies, bioreactor, ...)

Uses(4): Diagnostic

Uses(5): Therapeutic

Antibody applications: In vivo studies

Inserm Transfert
Research Tools

Species: Mouse

Genotype: Wild type axenic

Strain: C57bl6

Genetic Background: C57bl6

Applications: Metabolic diseases

Rare disease: No

Last update: 12/06/2024

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