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Rat transformed mesothelial cell line f5-3

Transformed rat mesothelial cell line (= myofibroblast) isolated from the peritoneal fibrosis observed in a female rat (Fischer F344) after 415 days of induction with crocidolite (blue asbestos) injected intraperitoneously.
Interest / Relevance: - Academic research: investigation of Epithelial Mesenchymal transition (EMT), studies of metastatic potential in malignancy, renal fibrosis...
- Industry research: antibody production, screening of new anticancer agents, identification of factors that increase mesothelial proliferation and migration.
- Therapeutic research: development of cancer vaccines, regenerative medicine applications.
Keywords: Mesothelial cells , Tumor marker , Tumor invasion process , Malignant transformation , Proliferation rate
Scientist's name: Daniel POULIQUEN

Reference:

RT00458

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Daniel POULIQUEN
Inserm Transfert
Research Tools
Organism: Rat
Tissue: Peritoneal fibrosis (transformed mesothelium)
Morphology: Fibroblastoid (myofibroblast-like cell line)
Passage Number: 4
Culture Medium: RPMI 1640 supplemented with 10% FCS and 2mM L-Glutamine
Karyotype: No, Cellular and Molecular Biology, Immunology.
Rare disease:
Last update: 08/02/2022

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