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Rat transformed mesothelial cell line f5-3

Transformed rat mesothelial cell line (= myofibroblast) isolated from the peritoneal fibrosis observed in a female rat (Fischer F344) after 415 days of induction with crocidolite (blue asbestos) injected intraperitoneously.

Interest / Relevance: - Academic research: investigation of Epithelial Mesenchymal transition (EMT), studies of metastatic potential in malignancy, renal fibrosis...rn- Industry research: antibody production, screening of new anticancer agents, identification of factors that increase mesothelial proliferation and migration.rn- Therapeutic research: development of cancer vaccines, regenerative medicine applications.

Keywords: Mesothelial cells , Tumor marker , Tumor invasion process , Malignant transformation , Proliferation rate

Scientist's name: Daniel POULIQUEN

Publications:

null

Reference:

RT00458

Type of research tool: Cell Lines

Therapy area(1): Infectious Diseases

Therapy area(2): Oncology

Therapy area(3): Others

Uses(1): Academic Research

Uses(2): Proof of concept in vitro

Uses(3): Industry Research (screening, tox.studies, bioreactor, ...)

Uses(4): Therapeutic

Inserm Transfert
Research Tools

Organism: Rat

Tissue: Peritoneal fibrosis (transformed mesothelium)

Morphology: Fibroblastoid (myofibroblast-like cell line)

Passage Number: 4

Subculture Routine: null

Culture Medium: RPMI 1640 supplemented with 10% FCS and 2mM L-Glutamine

Growth Properties: null

Karyotype: No, Cellular and Molecular Biology, Immunology.

Rare disease: No

Last update: 12/06/2024

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