Rat mesothelioma cell line f5-t1

Neoplastic rat cell line isolated from tumor masses (peritoneal mesothelioma) collected in the peritoneal cavity of a female rat (F344) after 392 days of induction with crocidolite (blue asbestos) injected intraperitoneously.

Interest / Relevance: - Academic Research: identification of markers of neoplastic / transformed mesothelial cells, analyses of chromosomal damage induced by asbestos, studies of the mechanism of asbestos-induced oncogenesis.rn- Industry research: antibody production, screening of new anticancer agents, identification of factors implicated in mesothelioma cell proliferation, migration, and invasion. rn- Therapeutic: development of epigenetic drugs, design of cancer vaccines.
Keywords: mesothelial cells , tumor marker , tumor invasion process , malignant transformation , proliferation rate
Scientist's name: Daniel POULIQUEN
Publications:
null

Reference:

RT00421

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Organism: Rat
Tissue: Tumor (mesothelioma)
Morphology: Sarcomatoid
Passage Number: 2, 3, 6
Subculture Routine: null
Culture Medium: RPMI 1640 supplemented with 10% FCS and 2mM L-Glutamine
Growth Properties: In 6-well plates (300,000 cells/well): Doubling time 24-48h. Saturation density >200,000 cells / sq-cm.
Karyotype: under investigation
Rare disease: No
Last update: 12/06/2024

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