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Rat mesothelioma cell line f4-t2

Neoplastic rat cell line isolated from tumor masses (peritoneal mesothelioma) collected in the peritoneal cavity of a male rat (F344) after 387 days of induction with crocidolite (blue asbestos) injected intraperitoneously.

Interest / Relevance: - Academic Research: identification of markers of neoplastic / transformed mesothelial cells, analyses of chromosomal damage induced by asbestos, studies of the mechanism of asbestos-induced oncogenesis.rn- Industry research: antibody production, screening of new anticancer agents, identification of factors implicated in mesothelioma cell proliferation, migration, and invasion. rn- Therapeutic: development of epigenetic drugs, design of cancer vaccines.

Keywords: mesothelial cells , tumor marker , tumor invasion process , malignant transformation , proliferation rate

Scientist's name: Daniel POULIQUEN

Publications:

null

Reference:

RT00419

Type of research tool: Cell Lines

Therapy area(1): Oncology

Uses(1): Academic Research

Uses(2): Proof of concept in vitro

Uses(3): Proof of concept in vivo

Uses(4): Industry Research (screening, tox.studies, bioreactor, ...)

Uses(5): Diagnostic

Uses(6): Therapeutic

Antibody applications: In vivo studies

Inserm Transfert
Research Tools

Organism: Rat

Tissue: Tumor (mesothelioma)

Morphology: Epithelioid

Passage Number: 5, 7

Subculture Routine: null

Culture Medium: RPMI 1640 supplemented with 10% FCS and 2mM L-Glutamine

Growth Properties: In 6-well plates (300,000 cells/well): Doubling time 48-72h. Saturation density >200,000 cells / sq-cm.

Karyotype: under investigation

Rare disease: No

Last update: 12/06/2024

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