Rat mesothelial cell line m1-1

Transformed rat mesothelial cell line isolated from the peritoneal fluid of a male rat (Fischer F344) after 257 days of induction with crocidolite (blue asbestos) injected intraperitoneously.

Interest / Relevance: - Academic Research: identification of markers of neoplastic / transformed mesothelial cells, analyses of chromosomal damage induced by asbestos, studies of the mechanism of asbestos-induced oncogenesis, implication of fibrosis and inflammation.
- Industry research: antibody production, screening of new anticancer agents, identification of factors that increase mesothelial proliferation and migration.
- Therapeutic: development of epigenetic drugs, design of cancer vaccines, regenerative medicine applications.
Cellular and Molecular Biology, Immunology.
Keywords: mesothelial cells , tumor marker , tumor invasion process , malignant transformation , proliferation rate
Scientist's name: Daniel POULIQUEN

Reference:

RT00424

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Daniel POULIQUEN
Inserm Transfert
Research Tools
Organism: Rat
Tissue: Mesothelium (peritoneal cavity)
Morphology: Mixt (sarcomatoid and epithelioid)
Passage Number: 5, 6
Culture Medium: RPMI 1640 supplemented with 10% FCS and 2mM L-Glutamine
Growth Properties: In 6-well plates (300,000 cells/well): Doubling time: 48-72h. Saturation density <
80,000 cells / sq-cm.
Karyotype: under investigation
Rare disease:
Last update: 08/02/2022

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