Pharmacologically active microcarriers for efficient integration of transplanted cells in the host tissue

This invention results from Pharmacologically Active Microcarriers (PAM) which are based on a biocompatible and biodegradable material. These particles made with poly(D,L-lactic-coglycolic acid) (PLGA) and coated with adhesion molecules may serve as a support for cell culture and may be used as cell carriers presenting a controlled delivery of active protein. They can thus support the survival and differentiation of the transported cells as well as their microenvironment and allow efficient integration of transplanted cells in the host tissue. The autors have demonstrated the therapeutic potential of PAM in various clinical applications (parkinson disease, cartilage repair, ischaemic stroke, regeneration of post-ischemic tissues,...). Exclusive license available outside cell therapy for animal osteoarticular and pulmonary diseases.

Keywords: cartilage repair, ischaemic stroke, regeneration of post-ischemic tissues, microparticle, Biomaterial, cell therapy, Regenerative medecine, cell delivery, Polymer
Patent Application number: PCT/FR03/01377
Inventors:
Marie-Claire VENIER Jean-Pierre BENOIT Claudia MONTERO-MENEI Philippe MENEI Valérie TATARD
Publications:
- Technology: Biomaterials. 2005 Jun;26(17):3727-37. Eur J Pharm Biopharm. 2008 Sep;70(1):127-36. doi: 10.1016/j.ejpb.2008.03.006. Epub 2008 Mar 16. Eur J Pharm Sci. 2012 Jan 23;45(1-2):128-37. doi: 10.1016/j.ejps.2011.10.030. Epub 2011 Nov 9. - Cartilage repair: Biomaterials. 2010 Sep;31(25):6485-93. doi: 10.1016/j.biomaterials.2010.05.013. Epub 2010 Jun 8. J Control Release. 2013 Aug 28;170(1):99-110. doi: 10.1016/j.jconrel.2013.04.017. Epub 2013 May 3. - Parkinson disease: Cell Transplant. 2004;13(5):573-83. Biomaterials. 2007 Apr;28(11):1978-88. Epub 2007 Jan 4. Bone. 2007 Feb;40(2):360-73. Epub 2006 Nov 3. Biomaterials. 2011 Feb;32(6):1560-73. doi: 10.1016/j.biomaterials.2010.10.041. Epub 2010 Nov 12. Stem Cells Transl Med. 2015 Jun;4(6):670-84. doi: 10.5966/sctm.2014-0139. Epub 2015 Apr 29. - Ischaemic stroke: J Neurochem. 2011 Dec;119(5):972-88. doi: 10.1111/j.1471-4159.2011.07272.x. Epub 2011 May 13. Acta Biomater. 2015 Mar;15:77-88. doi: 10.1016/j.actbio.2014.12.017. Epub 2014 Dec 31. - Regeneration of post-ischemic tissues: Eur J Pharm Biopharm. 2012 Aug;81(3):609-16. doi: 10.1016/j.ejpb.2012.04.014. Epub 2012 Apr 26. J Cell Mol Med. 2013 Jan;17(1):192-204. doi: 10.1111/j.1582-4934.2012.01662.x. Epub 2013 Jan 11.

Reference:

GBM01306-T1

Business Developper
contact
Elodie Acloque
Elodie Acloque
Business Developer
Patent filling date: 03-05-2002

You might also be interested in