we generated mice in which the model antigen influenza hemagglutinin (HA) is selectively expressed as a neo-self antigen in oligodendrocytes, referred as MOG-HA mice. In these mice upon adoptive transfer of preactivated HA-specific CD8 T cells led to inflammatory lesions in the CNS, These lesions, associating CD8 T cell infiltration with focal loss of oligodendrocytes, and subsequent demyelination