Methods for the diagnosis and thetreatment of graft-versus-hostdisease

The invention relates to methods for the prediction and the treatment of risk of acute graft versus host disease. The inventors demonstrated that an alteration of CD73-mediated regulatory function of DP8α Tregs could contribute to the acute GvHD pathophysiology. In particular, the present invention relates to method of determining whether a subject has or is at a risk of developing graft-versus-host disease (GvHD) comprising the steps of: i) determining the level of CD73 expression by DP8α TREGS in a sample obtained from the subject, ii) comparing the level determined at step i) with a predetermined reference value wherein detecting differential between the level of CD73 expression by DP8α TREGS determined at step i) and the predetermined reference value is indicative of whether a subject has or is at a risk of developing graft-versus-host disease (GvHD).

Keywords: Graft-versus-host disease, Prognosis, CD73 expression on Treg cells, hematological malignancies, allogeneic hematopoietic stem cell transplantation
Patent Application number: EP20 306 320.1 on 04/11/2020
PCT/EP2021/080557 on 03/11/2021

Reference:

BIO20418-D1

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Pierre MAZOT
Pierre MAZOT
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Patent filling date: 2020-11-04

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