Method and kits for diagnosis and response treatment prediction of inflammatory autoimmune diseases

The present invention relates to methods and kits for analysing the steady-state activation or inhibition of ITAM signalling of immunoreceptors in blood leukocytes. The inventors investigated that low valency ligands induced ITAMi signals by FcR, but also BCR and TCR, that were driven by Lyn or Lck recruitment followed by SHP-1 activation resulting in inhibition of heterologous activating receptors. In contrast, Fyn was required for multivalent ligand induced ITAM signals driving Syk or Zap-70 recruitment resulting in cell activating functions. In particular, the present invention relates to a method for analysing the activating or inhibiting steady-state of ITAM signalling of immunoreceptors in a population of leukocytes comprising by determining whether the immunoreceptors are associated with a Fyn-kinase activity or are associated with a Lyn/Lck kinase activity. Scientific publication(s): Nat Commun., 2017 Aug 15, Mkaddem SB. et al., Lyn and Fyn function as molecular switches that control immunoreceptors to direct homeostasis or inflammation, doi: 10.1038/s41467-017-00294-0.

Keywords: Inflammation, Autoimmune inflammatory diseases, Lupus
Patent Application number: EP16 305 683.1
Inventors:
Sanae BEN MKADDEMRenato MONTEIRO-COSTAEric DAUGAS
Publications:
Nat Commun. 2017 Aug 15;8(1):246. doi: 10.1038/s41467-017-00294-0.

Reference:

BIO16217-D1

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Sylvestre CHEA
Sylvestre CHEA
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Patent filling date: 2016-06-10

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