Hek 293 cells expressing human prolactin receptor and lhre-lucifease reporter gene

This stable clone of HEK 293 cells has stably incorporated the sequence encoding the long isoform of the human prolactin receptor and a prolactin-responsive reporter gene, the lactogenic hormone response element (LHRE, = repeat of Stat5 DNA binding sequence) fused to the firefly luciferase sequence

Interest / Relevance: This cell clone can be used to study any ligand (agonist or antagonist) of the human prolactin receptor, or any compound/ligand of other receptors that could interfere with prolactin receptor signaling. Application are in any field in which the prolactin receptor could have an effect. It is appropriate to study extracellular modifiers of prolactin recetor signaling.
Keywords: prolactin , prolactin receptor , luciferase , agonists , antagonists
Scientist's name: Vincent GOFFIN
1.Bernichtein S et al (2003) Endocrine 20: 177-190.rn2.Bernichtein S et al (2003) J Biol Chem 278: 35988-35999.rn3.Kinet S et al (1999) J Biol Chem 274: 26033-26043.



Business Developper
Inserm Transfert
Research Tools
Organism: Human fibroblasts
Tissue: Embryonic kidney
Morphology: Adherent cells
Passage Number: null
Subculture Routine: null
Culture Medium: Classical DMEM with additives
Growth Properties: Passage every 3 days
Karyotype: null
Rare disease: No
Last update: 12/06/2024

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