Establishment of redifferentiated cells after treatment of neoplastic invasive cell lines with curcumin

When undifferentiated, invasive neoplastic cell lines are treated with an optimal time / concentration combination of curcumin (under conditions producing dramatic cell death), a small proportion of surviving cells can undergo a process of redifferentiation. These clones of redifferentiated cells, together with the original tumor cells, could represent interesting biological tools for both academic research (onco-immunology, genetics / epigenetics) and industry research (for example design of cancer vaccines).

Interest / Relevance: The proof of concept has been established in vitro (in culture) on an invasive, undifferentiated sarcomatoid rat mesothelioma cell line (M5-T1) (see attached figure). Extension of this protocol to other types of experimental and human malignant tumor cell lines is in process.
Keywords: Redifferentiation , Neoplastic cells , Epithelial cells , Phytochemicals
Scientist's name: Daniel POULIQUEN

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