Anti-thex1 autoantibodies as biomarker for diagnosis of systemic lupus erythematosus (sle)

Lupus is a chronic autoimmune disease in which the immune system malfunctions cannot distinguish between foreign invaders and healthy tissue. Antibodies are produced against the body's healthy cells and tissues, causing inflammation, pain and damage in various parts of the body. The most common type is systemic lupus erythematosus (SLE), which is a connective tissue autoimmune disease, where vasculopathy is one of the most typical symptoms. It is mainly treated with immunosuppressive drugs or anti-inflammatory drugs. Many autoantibody species have been described in connection with lupus and their cognate antigens. Frequently the antigen is either poorly described or uncharacterised at the molecular level. Given the challenges in obtaining a correct diagnosis, there is a need for new or improved in vitro tests with better specificity and sensitivity to enable non-invasive diagnosis of lupus. The American College of Rheumatologists has established eleven criteria to assist in the diagnosis of lupus for the inclusion of patients in clinical trials and developed the SLE Disease Activity Index (SLEDAI) to assess lupus activity. Some of these criteria are very specific for lupus but have poor sensitivity, but none of these tests provides a definitive diagnosis and so the results of multiple differing tests must be integrated to enable a clinical judgement by an expert. Thus, the present invention relates to an in vitro method for diagnosing lupus in a subject, said method comprising the step of detecting in a biological sample obtained from the subject the autoantibody recognizing the protein biomarker THEX1. The invention also relates to kits and array useful for carrying out diagnosis methods according to the present invention. Scientific publication(s): PLoS One., 2016 Sep 12, Azzouz DF. et al., Anti-Ephrin Type-B Receptor 2 (EphB2) and Anti-Three Prime Histone mRNA EXonuclease 1 (THEX1) Autoantibodies in Scleroderma and Lupus, doi: 10.1371/journal.pone.0160283

Keywords: Systemic Lupus Erythematosus, SLE, Immunology, Auto-immune Disease, ELISA, Immunoassay
Patent Application number: EP14 305 364.3
PLoS One. 2016 Sep 12;11(9):e0160283. doi: 10.1371/journal.pone.0160283. eCollection 2016.



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Sylvestre CHEA
Sylvestre CHEA
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Patent filling date: 2014-03-13

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