Advanced cutaneous melanoma can be treated by immunotherapy targeting immune check points such as PD-1 and CTL-A4. However, 50% of patients do no […]
The present invention relates to N-(3-(5-(pyrimidin-4-yl)thiazol-4-yl)phenylsulfonamide compounds which are useful as inhibitors of protein kinases, […]
Here, in multi-scale analyses using single-cell RNA sequencing of six different primary uveal melanomas, inventors uncover a previously unrecognized […]
The invention relates to melanoma antigen named MELOE and their use for preventing, treating and diagnosing melanoma. […]
The present invention relates to method and composition for treating melanoma. The inventors have shown that a decrease in LYN expression, in melanoma […]
Immune checkpoint blockade therapy is based on the inhibition of the tumor-mediated suppression of anticancer immune responses. However, the efficacy […]
The present invention relates to methods for enhancing the potency of the immune checkpoint inhibitors. In particular, the present invention relates […]
The present invention relates to a method and composition for treating melanoma. More particularly, inventors have shown that high expression of USP14 […]
Immune checkpoint inhibitors (ICI) have revolutionized therapy for advanced cancer, however many patients still do not respond to treatment. However, […]