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Ex vivo gene therapy based vaccine with nucleic acid molecule encoding

The present invention relates to a method of treating a B-cell malignancy in a subject using a vaccine composition comprising a population of […]

A microrna switch regulates the rise in hypothalamic gnrh production

A method for diagnosing a reproduction-related disorder in an individual, comprising: a) measuring the level of a miR200 nucleic acid and/or miR155 […]

Modulator of wip1 levels to treat wolfram syndrome

The present invention relates to novel therapeutic ways for treating Wolfram Syndrome (WS) by targeting the neuronal calcium sensor 1 (NCS1). The […]

Method for the treatment of disease associated with angiogenesis

The present invention relates to a method of treating disease associated with angiogenesis using an N-Methyl-D-aspartate receptor (NMDA) antagonist. […]

Vdac1 inhibition for the treatment of peripheral demyelination

Here the inventors show, using in vivo imaging and viral approaches, that calcium released by mitochondrial VDAC1 directly induces Schwann cell […]

Protease nexin-1 inhibitor for the treatment of haemorrhagic disease

The thrombogram of FVIII-KO mice displays a prolonged time to peak and a reduced peak thrombin. The addition of the neutralizing anti-protease nexin-1 […]

Ptgdrs, cxcr4 and basophils in systemic lupus erythematosus

The present invention relates to PTGDRs, CXCR4 and Basophils to treat in Systemic Lupus Erythematosus. In particular, the present invention concerns a […]

Novel target candidate for the prevention and treatment of respiratory

The present invention relates to methods and pharmaceutical compositions for the prevention and treatment of respiratory bacterial infections and more […]

Ppar-gamma agonist as target for the treatment of rapidly progressive

This study demonstrates the pivotal role of the local PPAR-gamma agonist system in maintaining podocyte quiescence and orchestrating the global […]

Cdc25a phosphatase inhibitor for use in thetreatment of a drug

The invention relates to a CDC25A phosphatase inhibitor for use in the treatment of drug resistant cancer or for use in the prevention of tumor […]