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Novel b-raf inhibitors devoid of rapid metabolism and of binding to

The present invention relates to N-(3-(5-(pyrimidin-4-yl)thiazol-4-yl)phenylsulfonamide compounds which are useful as inhibitors of protein kinases, […]

New method to treat acidosis related diseases

The present invention relates to the treatment of acidosis related diseases. In this study, the inventors have investigated how human monocytes adapt, […]

Anti- protease nexin-1 conformational single domain antibodies and

The present invention relates to anti-protease nexin-1 (PN-1) conformational single domain antibodies and uses thereof in particular in the […]

Exon skipping therapy of erythropoietic protoporphyria

The present invention relates to methods and pharmaceutical compositions for the treatment of Erythropoietic Protoporphyria. In particular, the […]

Nanoblade technology: high efficiency delivery of crisprs components

The present invention relates to a virus-derived particle comprising one or more Cas protein(s), as well as to kits and methods using the same for […]

Antibodies specific to glycoprotein (gp) of ebolavirus and uses for

The present invention relates to antibodies or fragments thereof that specifically bind to glycoprotein (GP) of Ebola virus, and to their use for […]

Improved vector for driving the targeted integration of a transgene

The present invention relates to polypeptide for engineering integrase chimeric proteins and their use in gene therapy. rnA key challenge for gene […]