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Anti-neurotensin mab for the treatment of cancer

The present invention relates to a neutralising antibody which is capable of binding to neurotensin with high affinity. The antibody of the present […]

Combination of arsenic and interferon alpha for the treatment of

The present invention relates to methods and pharmaceutical compositions for the treatment of myeloproliferative disorders in patients presenting a […]

Retinoic acid and arsenic trioxide trigger degradation of mutated

The present invention relates to methods and pharmaceutical compositions for the treatment of acute myeloid leukemia. In particular, the present […]

Methods for the diagnosis and treatment of gastrointestinal stromal

The present invention relates to the diagnosis of gastrointestinal stromal tumors (GISTs). The present invention also relates to methods and […]

Human monoclonal antibodies against orexin receptor type 1

The present invention relates to human monoclonal antibodies against orexin receptor type 1 (OX1R) and uses thereof for the treatment of cancer. […]

A lyn kinase activator for the treatment of braf inhibitor-resistant

The present invention relates to method and composition for treating melanoma. The inventors have shown that a decrease in LYN expression, in melanoma […]

Sphingosine kinase 2 inhibitors in combination with immune checkpoint

Immune checkpoint blockade therapy is based on the inhibition of the tumor-mediated suppression of anticancer immune responses. However, the efficacy […]

Mutated strain for the development of attenuated vaccine against zika

The present invention relates to a genomic sequences encoding for an attenuated mutant Zika virus. The inventors have introduced some specific […]

Il15 antagonist to treat inflammation

The present relates to interleukin 15 (IL-15) antagonists and uses thereof, in particular for the treatment of autoimmune diseases and inflammatory […]

Lymphotoxin alpha regulates the immunosuppressive functions of

The present invention relates to regulatory T cell and uses thereof. By their immunosuppressive and anti-inflammatory activities, regulatory T cells […]