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Use of shp2 inhibitors for the treatment of insulin resistance

Despite reaching an epidemic status worldwide, metabolic disorders, notably diabetes, still miss efficient and specific therapeutic strategies because […]

Methods and pharmaceutical compositions for the treatment of chronic

The present invention relates to methods and pharmaceutical compositions for the treatment of chronic kidney disease. The inventors used the CMap […]

Use of pi3kc2¿ inhibitors for the preservation of vascular

Ischemic conditions are a leading cause of death for both men and women. Ischemia, a condition characterized by reduced blood flow and oxygen to an […]

Neutralizing granzyme b for providing cardioprotection in a subject

The present invention relates to a method for providing cardioprotection in a subject who experienced a myocardial infarction comprising administering […]

Methods and compositions for treating asthma and allergic diseases

The present invention relates to allergy field. Several independent groups have recently investigated the implication of PCSK9 on inflammation and […]

Novel melanoma antigens

The invention relates to melanoma antigen named MELOE and their use for preventing, treating and diagnosing melanoma. […]

Anti-cathepsin d human antibody for triple negative breast cancer

Inventors have generated two human anti-cath-D scFv fragments cloned in the human IgG1 ??format (F1 and E2) that efficiently bind to human and mouse […]

Triarylpyridine compounds and use thereof for treating cancer

The invention relates to new bis-triazole 2,4,6-triarylpyridines compounds and their use in the field of oncology, in particular in the prevention […]

Histone chaperone hira inhibitor for treating hepatitis b virus

The present invention concerns an inhibitor for use for preventing and/or treating an infection with hepatitis B virus (HBV) and an in vitro screening […]

A pak1/2 inhibitor for the treatment of psoriasis and other nlrp3

The present invention relates to a PAK-1 and/or PAK-2 inhibitor for use in the treatment of NLRP3 inflammasome mediated IL-1beta dependent disorders […]