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Ex-vivo active immunotherapy against infectious diseases and tumoral

The present invention concerns lentiviral vectors enabling the expression of membrane-anchored and secreted antibodies by B cells. This invention […]

Vdac1 inhibition for the treatment of peripheral demyelination

Here the inventors show, using in vivo imaging and viral approaches, that calcium released by mitochondrial VDAC1 directly induces Schwann cell […]

Protease nexin-1 inhibitor for the treatment of haemorrhagic disease

The thrombogram of FVIII-KO mice displays a prolonged time to peak and a reduced peak thrombin. The addition of the neutralizing anti-protease nexin-1 […]

Non-invasive imaging of tumor pd-l1 expression using radiolabeled

The present invention relates to a method for identifying patients sufferingrnfrom or suspected to suffer from a cancer involving a solid tumor […]

Apelin for the treatment of type 2 diabetes

Use of Apelin in humans has a positive effect on insulin sensitivity with a good tolerance and a good safety. Thus, a first object of the invention […]

Antibodies specific to glycoprotein (gp) of ebolavirus and uses for

The present invention relates to antibodies or fragments thereof that specifically bind to glycoprotein (GP) of Ebola virus, and to their use for […]

Improved vector for driving the targeted integration of a transgene

The present invention relates to polypeptide for engineering integrase chimeric proteins and their use in gene therapy. rnA key challenge for gene […]

Ptgdrs, cxcr4 and basophils in systemic lupus erythematosus

The present invention relates to PTGDRs, CXCR4 and Basophils to treat in Systemic Lupus Erythematosus. In particular, the present invention concerns a […]

Apelin analogs for the treatment of heart failure

The invention related to metabolically stable Apelin analogs and their use for the prevention or the treatment of diseases mediated by the apelin […]

Novel target candidate for the prevention and treatment of respiratory

The present invention relates to methods and pharmaceutical compositions for the prevention and treatment of respiratory bacterial infections and more […]