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Use of fzd7 inhibitors for the treatment of retinal neovascularization

Retinal ischemia and abnormal blood vessels growth are major determinants in the pathogenesis of retinopathy of prematurity (ROP) and proliferative […]

Ctip fusion to cas9 enhances transgene integration by

The present invention relates to nuclease protein fusions for enhancing genome editing by homology-directed transgene integration (HDI).rnrnThe […]

Inhibition of nicotinamide phosphoribosyltransferase (nampt) for the

The present invention relates to a method for treating a subject suffering from melanoma resistant by administering to said subject an inhibitor of […]

Methods of treating heart failure

Worldwide, 1% to 2% of the general adult population have heart failure (HF), which is accompanied by reduced quality of life, high morbidity, […]

Methods of enhancing the potency of incretin-based drugs in subjects

The present invention relates to methods of enhancing the potency of incretin-based drugs in subjects in need thereof. Through different animal […]

Methods and pharmaceutical compositions for cardiac regeneration

The adult mammalian heart regeneration is largely prevented by the limited proliferative capacity of the resident cardiomyocytes (CMs). Here, the […]

Trek1/trek2 as targets for the treatment of migraine

Inventors have found that the MT mutation puts an alternative start codon in frame which leads to the translation of a second TRESK fragment. […]

A checkpoint kinase 1 inhibitor sensitises cancer cells to

The present invention relates to the field of cancer treatment. In this study, the inventors sought to investigate whether this antiproliferative […]

Lipopeptide compound for the treatment of pain disorder

The invention is based on the discovery of a new bacterial compound with analgesic properties which could be used as a new tool for the treatment of […]

Methods and pharmaceutical compositions for the treatment of

The present invention relates to methods and pharmaceutical compositions for the treatment of age-related cardiometabolic diseases. In particular, the […]