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Methods and compositions for predicting and treating uveal melanoma

Here, in multi-scale analyses using single-cell RNA sequencing of six different primary uveal melanomas, inventors uncover a previously unrecognized […]

Methods and compositions for predicting and treating uveal melanoma

Here, in multi-scale analyses using single-cell RNA sequencing of six different primary uveal melanomas, inventors uncover a previously unrecognized […]

Novel melanoma antigens

The invention relates to melanoma antigen named MELOE and their use for preventing, treating and diagnosing melanoma. […]

A lyn kinase activator for the treatment of braf inhibitor-resistant

The present invention relates to method and composition for treating melanoma. The inventors have shown that a decrease in LYN expression, in melanoma […]

Sphingosine kinase 2 inhibitors in combination with immune checkpoint

Immune checkpoint blockade therapy is based on the inhibition of the tumor-mediated suppression of anticancer immune responses. However, the efficacy […]

Sphingosine kinase 1 a new tumor target for enhancing the potency of

The present invention relates to methods for enhancing the potency of the immune checkpoint inhibitors. In particular, the present invention relates […]

Methods and compositions for treating melanoma

The present invention relates to a method and composition for treating melanoma. More particularly, inventors have shown that high expression of USP14 […]

Stratification of melanoma patients for immune checkpoint inhibitor

Immune checkpoint inhibitors (ICI) have revolutionized therapy for advanced cancer, however many patients still do not respond to treatment. However, […]

New biomarker for prognosis and treatment of patients with melanoma

The present invention relates to a method and composition for treating melanoma, aggressive/invasive melanoma, metastatic melanoma or melanoma […]

Novel melanoma antigen peptide and uses thereof

The invention relates to peptides derived from the MELOE antigen for therapeutic vaccination against cancer. A phase I clinical trial for ex-vivo […]