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Profiling blood lymphocytes reactivity against cancer cells

In vitro trogocytosis of PKH67-stained cancer cells as a measure of their interactions with bulks of PBMC from patients. This profiling give the quantification of specific interactions of different subsets from PBMC with different cancer cells.

Interest / Relevance: This profiling provides interaction signatures for the immunomonitoring of cancers in case of cancer patients for example to adress the level of their immune system reactivity at diagnostic and/or during therapeutic treatment.

Keywords: immune reactivity , trogocytosis , immunomonitoring , interactions

Scientist's name: Mary POUPOT
Jean-Jacques FOURNIE,Frédéric PONT

Publications:

M. Poupot F. Pont and J.J. Fournié. 2005. Profiling blood lymphocyte interactions with cancer cells uncovers the innate reactivity of human gd T cells to anaplastic large cell lymphoma. Journal of Immunology 174(3): 1717-22.

Reference:

RT00436

Type of research tool: Know How

Therapy area(1): Oncology

Therapy area(2): Others

Uses(1): Academic Research

Uses(2): Proof of concept in vitro

Uses(3): Industry Research (screening, tox.studies, bioreactor, ...)

Inserm Transfert
Research Tools

Accessible for: Fee-for-service research, Collaboration, Training / Know-How License

Equipment available: This method require a flow cytometer with at least two lasers and at best three lasers.

Samples/Models available: null

Rare disease: No

Last update: 12/06/2024

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