Methods and pharmaceutical compositions for the treatment of cancers associated with an activation of the mapk pathway

The response of subjects suffering from cancer to MAPK inhibitors is dramatically impaired by secondary resistances and rapid relapse. So far, the molecular mechanisms driving these resistances are not completely understood. The inventors show that expression of SLITRK6 (SLIT and NTRK-like family, member 6) is induced by a MAPK inhibitor (e.g. Vemurafenib) and the inhibition of its induction in presence of the MAPK inhibitor induces synthetic lethality. Thus, the only inhibition of SLITRK6 by an inhibitor of activity or expression should potentiate the antitumor effect of the MAPK inhibitors and avoid the emergence of a resistance to those compounds. Furthermore the specific expression ofrnSLITRK6 also paves the way of strategies based on depletion of the residual cancer cells byrntargeting them with anti-SLITRK6 antibodies capable of mediating ADCC or antibody-drugrnconjugates binding to SLITRK6rn

Keywords: ELISA, IHC, RT-PCR, Western Blot, Immunoassay, Transcriptomics, Treatment response, Prognosis, Oncology, Solid Tumor, Melanomarn
Patent Application number: European Procedure (Patents) (EPA) - 10 Févr. 2017 - 17 305 153.3



    Business Developper
    Inserm Transfert
    Business Developer
    Patent filling date: 09-02-2018
    Rare disease: No
    Second indication: No

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