New molecules for neurodegenerative pathologies : indirect ?-secretase

The present invention is directed to novel compounds and pharmaceutically acceptable salts or solvates thereof, and their use. […]

Pyk2-based gene therapy gene therapy attenuates cognitive deficits

In the present invention it is shown that the inactivation of the Pyk2 gene does not alter hippocampal development but prevents hippocampal-dependent […]

A progression model that estimates a normative scenario of the

The invention relates to age-related brain diseases, such as Parkinson’s or Alzheimer’s disease. Statistical models based on the regression of […]

Soluble apps?-based gene therapy in alzheimer’s disease

The present invention relates to a method of treating Alzheimer’s disease by administration to the subject of a therapeutically effective amount of […]