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Neutralizing granzyme b for providing cardioprotection in a subject

The present invention relates to a method for providing cardioprotection in a subject who experienced a myocardial infarction comprising administering […]

Methods and compositions for treating asthma and allergic diseases

The present invention relates to allergy field. Several independent groups have recently investigated the implication of PCSK9 on inflammation and […]

Combination of arsenic and interferon alpha for the treatment of

The present invention relates to methods and pharmaceutical compositions for the treatment of myeloproliferative disorders in patients presenting a […]

Methods for the diagnosis and treatment of gastrointestinal stromal

The present invention relates to the diagnosis of gastrointestinal stromal tumors (GISTs). The present invention also relates to methods and […]

Sphingosine kinase 2 inhibitors in combination with immune checkpoint

Immune checkpoint blockade therapy is based on the inhibition of the tumor-mediated suppression of anticancer immune responses. However, the efficacy […]

Lymphotoxin alpha regulates the immunosuppressive functions of

The present invention relates to regulatory T cell and uses thereof. By their immunosuppressive and anti-inflammatory activities, regulatory T cells […]

Sphingosine kinase 1 a new tumor target for enhancing the potency of

The present invention relates to methods for enhancing the potency of the immune checkpoint inhibitors. In particular, the present invention relates […]

Antagonists of il-33 for use in methods for preventing ischemia

Inflammation is a prominent feature of ischemia-reperfusion injury (IRI) characterized by leukocyte infiltration and renal tubular injury. However, […]

Ngal as a novel target for the treatment of chronic kidney disease

The severity of renal lesions after nephron reduction varied substantially among mouse strains and required activation of EGFR. Lipocalin 2 (Lcn2, […]

Methods and compositions for treating liver disesases

The present invention relates to a method for treating a subject suffering from a liver disease comprising a step of administering said subject with a […]