Use of irap inhibitors for the treatment of inflammatory diseases

Upon activation, mast cells rapidly release preformed inflammatory mediators from large cytoplasmic granules via regulated exocytosis. This acute […]

Use of hedgehog inhibitors for the treatment of mastocytosis

The inventors demonstrate for the first time the activation of the Hedgehog (HH) signaling pathway in normal and abnormal human mast cells (MCs). […]

Methods and composition to identify and treat subjects resisting to

The present invention relates to a method for treating a subject suffering from a cancer comprising a step of administering said subject with a […]

Ivig composition and method of treatment of antibody deficient

The invention is in the field of therapy of antibody deficiencies such as immune diseases and inflammatory disorders. The inventors demonstrate for […]

Nanobody against ela2a to treat inflammatory bowel diseases (ibd) or

The invention is in the field of therapy of gut inflammatory diseases such as Inflammatory Bowel Diseases (IBD) or Irritable Bowel Syndrome (IBS) […]

Methods and compositions for modulating macrophages polarization

Inventors have surprisingly found that Emricasan is a much more potent inhibitor of monocyte differentiation compared to q-VD-OH by its ability to […]

Methods of treatment of inflammatory bowel diseases

Inventor’s general objective was to investigate the potential role of mucosal thrombin in intestinal inflammation and its mechanisms of action. […]

Use of inhibitors of phosphatase activity of soluble epoxide for the

The growing prevalence of obesity and type 2 diabetes complicates risk and clinical management by potentiating and/or exacerbating hypertension, […]

Use of retinoic acid receptor (rar) agonists forreversin g,

Aortic valve calcification is a condition in which calcium deposits form on the aortic valve in the heart. These deposits can cause narrowing at the […]

Use of mast cell stabilizer for the treatment of heart failure with

Heart failure with preserved ejection fraction (HFpEF) which results from diastolic dysfunction is a growing epidemiologic problem. However, the […]