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Rat mesothelial cell line f1-2
Transformed rat mesothelial cell line isolated from the peritoneal fluid of a female rat (Fischer F344) after 306 days of induction with crocidolite (blue asbestos) injected intraperitoneously.
Interest / Relevance:
- Academic Research: identification of markers of neoplastic / transformed mesothelial cells, analyses of chromosomal damage induced by asbestos, studies of the mechanism of asbestos-induced oncogenesis, implication of fibrosis and inflammation.
- Industry research: antibody production, screening of new anticancer agents, identification of factors that increase mesothelial proliferation and migration.
- Therapeutic: development of epigenetic drugs, design of cancer vaccines, regenerative medicine applications.
Keywords:
mesothelial cells , tumor marker , tumor invasion process , malignant transformation , proliferation rate
Scientist's name:
Daniel POULIQUEN
Reference:
RT00409
Type of research tool:
Cell Lines
Therapy area(1):
Oncology
Therapy area(2):
Immunology
Uses(1):
Academic Research
Uses(2):
Proof of concept in vitro
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Organism:
Rat
Tissue:
Mesothelium (peritoneal cavity)
Morphology:
Epithelioid
Passage Number:
4
Culture Medium:
RPMI 1640 supplemented with 10% FCS and 2mM L-Glutamine
Growth Properties:
In 6-well plates (300,000 cells/well): Doubling time >
72h. Saturation density <
80,000 cells / sq-cm.
Karyotype:
under investigation
Rare disease:
Last update:
08/02/2022
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